The endocannabinoid systems’ design matches endocannabinoids, or phytocannabinoids, found in the cannabis plant. Examples of phytocannabinoids are THC and CBD. THC and CBD are the most studied phytocannabinoids of the cannabis plant. Around 144 different phytocannabinoids have been isolated from the cannabis plant. Integrated Hemp Solutions’, RitualX CBD oil, is a full spectrum, hemp derived CBD oil, designed to bring the ECS back into balance.
With the passing of the 2018 Farm Bill, hemp is now legal in all 50 states. Regulations for cultivation, manufacturing, commerce, and regulations for lab testing will soon be disclosed to the public. Companies are not allowed to give specific dosing recommendations because CBD remains unregulated by the FDA. This is actually alright because CBD dosing is highly individualized. One person may need 1 drop of tincture a day to alleviate symptoms, while another person with the same condition could require 50 or 100 drops. In general, the greater a person’s internal cannabinoid deficiency, the more phytocannabinoids they will require. Known factors that affect dosing include:
- The current state of the individual’s Endocannabinoid System
- The body’s sensitivity to CBD
- The person’s body weight. Lighter people usually require less CBD
- The person’s general health and mitochondrial function
- The person’s age. Younger people usually require less CBD
CBD’s effects are biphasic, meaning that if you take too much while you are awake, you may become too drowsy instead. Small doses will wake you up and large doses will sedate you.3 In higher doses, CBD can cause drowsiness.4If you are affected in this way, you should not operate machinery or drive a vehicle. In most cases, however, CBD is a wake-inducing agent. Alternatively, high doses of CBD can be used as a very effective sleep aid, activating serotonin and melatonin receptors, raising dopamine levels during sleep, and promoting photoentrainment (the tying of circadian rhythm to sunlight cycles).
With CBD, less is often more. Start with low doses and increase weekly as needed to find your own minimum effective dose. The concept of the Biphasic Effect, or two-phase effect, applies to CBD dosing in that diminishing returns will begin at some point as you take more and more CBD.5
This biphasic effect applies to dose changes over time, too. As a person becomes healthier from consistent Hemp use, their Endocannabinoid System is strengthened. When this happens, the body’s demand for external help (in the form of phytocannabinoids) will be reduced, and an individual’s optimal dosing curve will ‘shift’ to the left. What was once an optimal dose may become too high. If this person, who is now healthy, fails to lower their dose, they will likely find themselves on the wrong side of the dosing curve.
Consult your doctor first, to let them know you are taking CBD oil. CBD can interfere with the way other prescription medications and OTC medications are removed from your body through your liver.6 Take your CBD oil at the same time every day, at least an hour after other medications. Start low and go slow. The effects of CBD are subtle and may take weeks to build up to your desired dose.
It is best to start out at a low amount of CBD, such as 4 mg. Increase your dosage slowly, every three days. Increase by a few milligrams at a time. Your symptoms, such as pain or anxiety, should slowly be improving as you increase your dosage. Consider taking your CBD oil every 4 to 6 hours to achieve consistent results throughout a 24 hour period. Hold the CBD oil under your tongue for at least 1 minute, before swallowing your CBD oil. This allows for the sublingual absorption of the CBD oil, and improved bioavailability of the phytocannabinoids.
Consider doing a Mindful Dosing Guide survey once a day, in a quiet place. Check out an example of a Mindful Dosing Guide below. Note how you feel and adjust your dose accordingly. Go up in dosage slowly to achieve relief of symptoms. When the dosage is increased steadily every week, combined with the mindful dosing guide, it is easier to lock down the precise amount of milligrams you need. You save CBD oil and money.
Mindful dosing guide:
|Pain, Mind, Breath, Body||Angry/Anxious – Joyful/Content||Short/Uneven – Relaxed/Smooth||Tightness/Tension Fluid/Comfortable|
Pain: On a scale of 1-10, 10 being the worst possible pain, rate your pain.
- 0-no pain
- 1-3 mild pain
- 4-6 moderate pain
- 7-10 severe pain
Keeping a journal is a good idea! It can help you establish a consistent routine and will help you better evaluate how your current dosage is working for your health needs. This individualization is completely different from how physicians and patients manage prescription medications, which understandably leads to confusion on how much CBD to take.
If you don’t feel anything at first, don’t get frustrated. It just means that you haven’t found your ideal dosage yet. Some people feel the effects immediately, for others it takes weeks. You may end up at a higher dose than you originally thought. The modulation of the Endocannabinoid System that is so critical to your health, it can take time.
A review paper on the Safety and side effects of CBD by the NCBI suggests that controlled CBD administration is safe and non-toxic in humans and animals. According to this review paper, “high doses up to 1,500 mg/day of CBD are reportedly well tolerated in humans.”
More Dosing Advice:
- Our CBD oil tinctures come in 3 different concentrations: 250 mg, 500 mg, and 1000 mg. Once you have determined how much your daily intake is, you will know what size concentration of CBD oil you will need. For example: If someone takes 50 mg/day, their ideal concentration of tincture would be the 1000 mg strength tincture.
- Start with the lowest concentration of the product and slowly work your way up to find your individualized dose. Consider weekly increases as needed.
- Take the product consistently, every day.
- Most individuals start taking their CBD at night. Many soon report that CBD promotes a sense of calm and relaxation. Improved quality & quantity of sleep is also often reported.
- Be patient. Your body needs to adjust to this new supplement.
- After your body has become accustomed to your new CBD product, you may choose to take it 2-3 times a day to see more consistent benefits.
- After months of consistent CBD use, patients on a high dose (50 mg/day+) may consider taking monthly “reset days” where supplemental use ceases. This may serve to maintain ECS receptor sensitivity and increase results and affordability in the long run.
- Shenglong, Z., et al. Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International Journal of Molecular Sciences. MDPI.2018 Mar.; 19(3): 833.ncbi.nlm.nih.gov/pmc/articles/PMC5877694/
- Smith SC, Wagner MS. Clinical endocannabinoid deficiency (CECD) revisited: can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? Neuroendocrinology Letters. Maghira and Maas Publications. 2014;35(3):198-201. ncbi.nlm.nih.gov/pubmed/24977967
- Murillo-Rodríguez E et al. The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent. Behavioral Neuroscience J. American Psychological Association. 2008 Dec;122(6):1378-82.ncbi.nlm.nih.gov/pubmed/19045957
- Babson KA et al. Cannabis, Cannabinoids, and Sleep: a Review of the Literature. Curr Psychiatry Rep. 2017 Apr;19(4):23.Frontline Medical Communications. ncbi.nlm.nih.gov/pubmed/28349316
- Alejandro Aparisi Rey et al. Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission. Neuropsychopharmacology J. Oxford University Press. 2012 Nov; 37(12): 2624–2634.ncbi.nlm.nih.gov/pmc/articles/PMC3473327/
- Zendulka O et al. Cannabinoids and Cytochrome P450 Interactions. Curr Drug Metab J. Bentham Science Publishers. 2016;17(3):206-26.10.ncbi.nlm.nih.gov/pubmed/26651971